The newly elected French National Assembly will be the most diverse ever, with younger and more ethnically diverse MPs.
The winning score was lower than forecast during the past week when some estimates suggested REM and its allies could secure as many as 470 seats.
"You could take a goat and give it Macron's endorsement and it would have good chance of being elected", political analyst Christophe Barbier joked recently.
In a letter to European Commission president Jean-Claude Juncker, French PM Philippe said that the new majority "embodies a France that is resolutely modern and determined to fall within a strong European future".
The ministry said the far-right National Front was in third place with almost 10% followed by the Socialists with 6.2%.
"We are the only force of resistance to the dilution of France, of its social model and its identity", Le Pen said, claiming the mainstream opposition parties were but "satellites" of the Macron power structure.
Le Pen said she would "fight with all necessary means the harmful projects of the government", especially what she called Macron's pro-European, pro-migrant policies.
After five years of Socialist Party rule, in which former President Francois Hollande failed to meet his objectives of reducing unemployment and giving a boost to the flagging economy, the French were depressed and downbeat.
But with his twin victories in last month's presidential election and Sunday's parliamentary vote, he has routed the old political class. "The president of the Republic has all the powers", Jean-Christophe Cambadelis said after announcing he would step down as Socialist Party chief.
They include 27-year-old Rwandan orphan Herve Berville, who cruised to victory in the western region of Brittany, and woman bullfighter Marie Sara, who came within 100 votes of unseating senior FN figure Gilbert Collard in southern France.
France's traditional left and right wing parties fared less well in the election. It was forecast to win only between 10 and 30 seats.
Macron's En Marche! and his centre-right allies from MoDem made off with about 360 seats in the country's parliament.
A record-low turnout marred the vote with far less than France's 47.5 million eligible voters bothering to cast ballots amid widespread disillusionment with politics and voter fatigue following several roller coaster campaigns and voting.
- Warriors-Cavaliers generate highest ratings for Finals series since Michael Jordan era
- SNP hold North Ayrshire as election ends in hung parliament
- Jelena Ostapenko prevails over 11th seed Caroline Wozniacki
- India sweep aside insipid South Africa to reach Champions Trophy semi-finals
- How Draymond Green Helped Make Kevin Durant's Move to Golden State Happen
- Zaman, Ali heroics helps Pakistan clinch Champions Trophy title
- SNP MSP: Indyref2 plans cost party 'a lot of votes'
- Cosby alternate juror 'probably' would have voted to convict
- In Georgia, costliest US House race hits ugly note as election looms
- Gorkhaland movement: GJM calls for indefinite strike across Darjeeling from Monday