Uber has also been dealing with an intellectual property lawsuit from Google's parent company, Alphabet, over alleged theft of trade secrets related to driverless cars. Some of the positions that Uber has open include a chief operating officer and a chief financial officer - and now, obviously, CEO.
Being that the advised overhaul came from a man who once served as the country's chief law enforcement official, it's no surprise that Uber's investors were eager for change.
Since co-founding the business with partner Bill Gurley in 2009, Kalanick has led the firm to realise a market value of around $68 billion (R886 billion). After a video showing Kalanick berating an Uber driver who had complained about falling wages was released in February, the CEO made a public apology and promised to seek "leadership help".
In addition to demanding Kalanick's resignation, the investors' letter asked for improved oversight of Uber's board by requesting that two of its three empty seats be filled with "truly independent directors".
The New York Times was the first to report the story late on Tuesday night.
The company's problems are not confined to its internal battles over bullying and harassment.
Other executives to have left this year include president Jeff Jones, senior vice-president of engineering Amit Singhal, head of policy and communications Rachel Whetstone, vice-president of maps Brian McClendon, vice-president of product and growth Ed Baker, and head of finance Gautam Gupta.
"There are a few other instances like this", said Ramsey, "though the circumstances are different". He was sacked earlier this month amid claims he obtained the medical records of a woman who was raped by an Uber driver in 2014. Alexander was sacked earlier this month. But Huffington, a founder of Huffington Post, suggested time might be running out.
"Over the years we have neglected parts of our culture as we have focused on growth".
We're thankful for your support in every way.
Kalanick will continue to stay on the board of directors.
"There's a strong gravitational pull in the Valley to support founders as long as you possibly can".
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