So much has changed since 2001, and not just the outfits and the hairstyles..
On Monday, it was the Williams who is not on the comeback trail who emerged as the victor.
"I wish it was anybody else in the draw, literally anybody, but that's OK, " Serena Williams said at a news conference Saturday after her 7-6 (5), 7-5 second-round victory over 29th-seeded Kiki Bertens of Netherlands that set up the match-up at the Indian Wells Tennis Garden.
Few have handled Serena - the record 23-time grand slam victor - as well as Venus, as evidenced by their head-to-head record.
Serena had won eight of their previous nine encounters, including last year's Australian Open final in Melbourne that gave her a 23 Grand Slam title.
Venus, seeded eighth, reached the Wimbledon final, the US Open semi-finals and the championship match of the WTA Finals while Serena was away from the tour.
When Serena is missing some of those shots, she says she isn't being as harsh on herself as in the past with her daughter in mind.
In this case, it was younger sister Serena's first tournament back in almost 14 months, after a baby and a wedding and some frightening post-birth complications.
In the 28 matches played, Serena has won 17 times compared to Venus' 11 victories.
"It's different, I haven't played in over a year". Or I'll get angry about the crying, then sad about being angry, and then guilty, like, Why do I feel so sad when I have a attractive baby?
"But I don't know how much lighter I can go".
The 20-time Grand Slam champion said the sisters' story has been fascinating for him to follow from the very start. But she also came up with winners under duress.
"I didn't really feel comfortable out there today (and) didn't really get my game going the way I wanted to", the Danish victor said. "It's a little bit of everything that comes in a match that just doesn't normally happen".
Venus was impressed by her younger sister's standard of play and believes the fact she has played more competitive matches was a decisive factor. "I was just lucky taht i played more matches than her right now", Venus said. Serena admitted that she cried in the locker room for "hours" after defeating Clijsters. At one point, Williams faced a tough question about her use of prednisolone, a drug banned by tennis authorities.
- Trump halts Qualcomm takeover by Broadcom for national security
- I am letting myself and the team down: Kagiso Rabada
- Pennsylvania election to be a test of pre-midterm Democratic appeal
- When is the next WWE PPV after Fastlane?
- American Idol tries for second act on new network
- Carragher apologizes for spitting at 14-year-old girl
- Manchester United Star Missing From Training Ahead of Sevilla Clash
- Browns LT Joe Thomas compares Tyrod Taylor to Russell Wilson
- Sevilla prepared to 'suffer' against Man United at Old Trafford - Montella
- At least two teams willing to offer Kirk Cousins fully guaranteed deal