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The State Department says it is monitoring reports of the possible chemical weapons attack.
Trump also called Syrian President Bashar al-Assad an "animal". "With this use of poison gas, the circumstances point to Assad regime's responsibility".
Trump threatened action, although it was unclear what he had in mind.
There has been at least a half dozen suspecting chemical attacks in Syria the USA president launched the air strikes, which meant to deter. Trump tweeted yesterday that the "area of atrocity is in lockdown and encircled by Syrian Army, making it completely inaccessible to outside world".
"We call on the Assad regime and its backers, Russian Federation and Iran, to stop the violence against innocent civilians".
Trump on Monday promised a decision on Syria within hours, declaring that Russian Federation or any other nation found to share responsibility for Saturday's apparent chemical weapons attack on civilians will "pay a price". Any military action should be limited in scope with clear objectives, because we can not become entangled in another civil war in the Middle East. He said the allegation that the Syrian regime is behind the attack "is not compatible with reality". However gaining access to samples on the ground would be hard. The U.N. Security Council held an emergency meeting on Monday, and President Donald Trump said "major decisions" on Syria would come within 24 to 48 hours.
SANA said buses had been sent to the town to pick up prisoners released by the militants and to transport rebel fighters to opposition-held territory in north Syria.
Turkish President Recep Tayyip Erdoğan expressed concern to Russian counterpart Vladimir Putin over attacks in Eastern Ghouta on April 9, the Turkish presidency said. It was once one of the hubs of the 2011 Arab Spring uprising against Assad's government. "The question now is whether he will do anything about it", McCain said in a statement. When asked if the United States would respond in a similar way to this latest alleged chemical attack, White House adviser Tom Bossert told ABC television: "I wouldn't take anything off the table".
Local activists told NBC News that they saw dozens of dead bodies, many of whom were children, in the underground shelters across the city.
April 7, 2018: A suspected chemical attack kills at least 40 people in Douma.
The reports could not immediately be independently verified. Americans are desperately in the quest for legitimate intervention in Syria possibly for another strike against government targets.
A medical worker gives a toddler oxygen through a respirator following an alleged poison gas attack
Labour said that anyone found guilty of using chemical weapons should be brought to justice and called for "concrete steps on all sides to restart meaningful talks on a political solution and lasting peace in Syria".
The agreement will be enforced by Russian military police, who will enter the city, opposition negotiators said.
Saturday's suspected poison gas attack on the besieged town of Douma came nearly exactly a year after the US missile attack prompted by the Khan Sheikhoun deaths.
Iran's foreign ministry said the reports were an excuse for military action against Damascus, the IRNA news agency reported. RT discussed the allegations with Middle East analysts. Trump has declared his intent to withdraw USA troops from Syria in the coming months, despite resistance from many of his advisers.
A doctor at the scene said some patients had suffered from hemoptysis or coughing up blood, a symptom that has never been seen in previous chemical attacks in Syria.
Witnesses and medical workers reported as many as 60 deaths, with almost a thousand injured after at least two bombs hit a hospital and nearby buildings.
It follows a weeks-long government offensive in which more than 1,600 people were killed. It said the attack left people dead and wounded.
Numerous people had been staying in underground shelters.
Douma is in the eastern Ghouta region near Damascus.
There was no immediate comment from the group.
Rami Abdurrahman, the Observatory's chief, said most of those killed were either Iranians or members of Iran-backed groups.
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