Russia, Syria's main military ally, strongly opposes such action.
They "are responsible for the regional consequences of this adventurist action", it added.
Mattis said "right now this is a one-time shot" but is not ruling out further attacks.
Russian Federation has also said that its military will retaliate for any airstrikes against Syria, meaning that US-military action could prompt a large global conflict. Meanwhile, Sweden has proposed asking the UN Secretary-General, Antonio Guterres, to suggest an impartial mechanism to assign blame for the chemical attack in Syria.
The base was attacked on Monday, allegedly by Israel, in a strike that reportedly targeted Iran's entire attack drone weapons system - prompting soaring tensions between Israel and Iran.
Hundreds of Syrians are demonstrating in a landmark square of the Syrian capital, waving victory signs and honking their auto horns in a show of defiance. Some demonstrators shouted: "We are your men, Bashar!"
"There is no doubt that the U.S. and its allies that are engaged a military intervention in Syria without any substantiated document and before any final report of the Organization for Prohibition of Chemical Weapons (OPCW), and have supposed themselves as the world police and judge, are responsible for regional and global repercussions of the adventure, and should be held accountable", he said.
Four Royal Air Force Tornado jets using Storm Shadow missiles had taken part in the attack on a military facility near Homs where it was assessed Syria had stockpiled chemicals, Britain's Ministry of Defence (MoD) said.
British Prime Minister Theresa May said in her country Saturday, according to Reuters, that the attack was "not about intervening in a civil war".
Asked if the United States and its allies would continue military operations, he said: "That will depend on Mr Assad should he decide to use more chemical weapons in the future, and of course the powers that have signed the Chemical Weapons Prohibition (Organisation for the Prohibition of Chemical Weapons) have every reason to challenge Assad should he choose to violate that".
It is understood Russian Federation threatened to cut off the line after the strikes in 2017.
Some non-governmental organizations, including White Helmets, claim that chemical weapons were used in Douma, Eastern Ghouta, on April 7.
United States aircraft including B-1 bombers and ships were used in the attack, USA defence officials said.
The U.S., France and the United Kingdom launched an overnight strike on multiple Syrian targets Saturday, in response to Bashar Assad regime's chemical attack a week ago. He says one of the missiles hit the Scientific Research Center in Barzeh near Damascus, damaging a building.
Defense Minister Florence Parly told reporters Saturday that the French military sent fighter jets from multiple bases in France and used missile-equipped frigates in the Mediterranean in the operation. On April 11, 2018, Trump set the stage for the action by labeling Syrian president Bashar al Assad a "gas killing animal".
A Syrian opposition official, Hadi Al Bahra, also tweeted "the first missile targeted an area in Mount Qasioun". From a distance, U.S. missiles hitting suburbs of the capital sounded like thunder.
The army said almost 110 missiles hit targets in the capital Damascus and other territory, and air defence systems brought a lot of them down.
Regime allies condemned the attack while those in favor of the strikes called them an "appropriate response".
The Mezzeh military airport southwest of the capital was said to be a target, as well. The aircraft use Paveway IV laser-guided bombs and Brimstone missiles to target strikes.
"The U.S. Has no appetite for war", Hudson told News 4 Tucson's Eric Fink.
USA aircraft including B-1 bombers and ships were used in the attack, according to multiple U.S. defense officials.
At the United Nations meanwhile, diplomats were mulling a draft resolution put forward by Sweden and obtained by AFP, that would dispatch a "high-level disarmament mission" to rid the country of chemical weapons "once and for all".
There are 192 signatories to the United Nations' Convention on the Prohibition of Chemical Weapons.
Analysts and experts have speculated whether Russian Federation will respond to the attacks.
The Syrian government has repeatedly denied any use of banned weapons.
Trump has long criticized his predecessor Barack Obama for failing to enforce a "red line" in 2013 after earlier chemical attacks blamed on Assad's forces.
The strikes, Defense Secretary James Mattis said in a late Friday press conference, were not the opening of a broader campaign.
Syria has not reacted formally so far till 10.15 am (IST).
But Syria and an independent monitoring group said planes were able to take off from the base again within hours.
- Hearing related to Federal Bureau of Investigation raid at Trump lawyer's office is set
- No "final decision" yet on Syria response, White House says
- Woman killed in crash on Hwy 148 near Quyon
- Trump 'Unhappy' With Syria Retaliation Options Presented to Him, 'Seeks Large Strike'
- No Joel Embiid in Sixers vs Heat Game 1
- CBAY) — CymaBay Therapeutics (NASDAQ
- USA concerned about triggering wider war as it weighs strike on Syria
- Strikes on Syria did not hit areas near Russian bases: Moscow
- AB de Villiers Takes RCB Home Against KXIP
- Mark Zuckerberg's data was collected by third parties