The Sixers badly needed injured All-Star center Joel Embiid to settle them.
Embiid remained out Monday despite clearing the NBA's concussion protocol.
At least once during this series Dwyane Wade was going to have a game that made everyone think it was 2006.
The 36-year-old scored 28 points (11-of-16 from the field) in 26 minutes off the bench, to lead Miami to a 113-103 road victory.
The Sixers were in red-hot form in the build-up to the contest with their crushing 130-103 Game 1 win over the Heat last week making it 17 consecutive wins for head coach Brett Brown's side.
Game 3 is Thursday as the series shifts to San Antonio.
The Sixers made something out of nothing as things got close down the stretch. The lead was built back to 12 but the temperature rose a bit on a highlight-reel play, with Dario Saric playing quarterback and throwing a three-quarter court pass to a streaking Ben Simmons, who punished the rim with a dunk. "This game equals the National Basketball Association playoffs".
Whiteside was terrible in Game 1 on Saturday night, scoring two points on 1-for-4 shooting with two turnovers in 12 minutes. The series is now tied 1-1 heading back to Miami.
Miami's starters moved the ball and forced the young Sixers to make decisions, something Philly was inconsistent at. Robert Covington was 1 for 8. "He was class. He was a gentleman", Brown said. "Some of our guys had a rough night. To be able to come through for your team when they need you feels good". With the Sixers closing the gap to two with a little over four minutes left, the wily veteran made a heady play.
The Sixers without Embiid struggled to score in the halfcourt.
Philly missed some open 3-pointers, but Miami's physical defense deserves credit for disrupting shooters.
"I just came in with an aggressive approach", Wade said afterwards. "Their ball pressure was excellent".
Dwyane Wade snuffed out one 76ers' rally by popping a 16-foot fadeaway with the shot clock ticking down.
At the same time, the Sixers weren't scoring the same way.
Durant finished with 32 points, six rebounds and six assists while Thompson had 31 points with five assists.
The fans in Philadelphia expected to see the Sixers take a 2-0 series lead over the Miami Heat on Monday night, and why would they think otherwise with the Sixers having a 24-2 record at home since Christmas?
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