The world number two has also now not dropped serve since the semi-finals previous year. That year Federer beat Gilles Simon on No. 1 Court in the quarterfinals.
Gulbis has played 3 successive 5-set matches to get this far and is bidding to become just the 6th qualifier to reach the last-8 at Wimbledon.
But is the Serb's recovering game sound enough yet, or his elbow sufficiently strong to keep rattling down those aces, to intimidate a player made in Edmund's power-play mode, Karen Khachanov, in the third match on No 1 Court on Monday?
"It's what I wished for", said Djokovic when asked if he would have preferred to move to Centre Court.
The world number one, chasing an 18th major, will now take on Del Potro boasting a 10-5 career lead.
And this year is turning out to be a flawless environment for Rafa to reestablish his winning ways at the All-England Club.
The two-time Wimbledon victor is sitting out of the tournament as he continues his rehab from a hip injury, but stepped into the BBC studio at the All England Club to assess the form of his greatest rivals. The last time two German women reached any Grand Slam semifinals was at the 1993 French Open, featuring Steffi Graf and Anke Huber.
(25) Serena Williams bt. "But things are looking much better in the last month and a half". I lost in the fourth round against a player I can lose to (Nick Kyrgios), 2015 was a very bad year for me, not on grass, on most of the surfaces. The tie break brought more good tennis and it was the Argentinian who went through after a crucial mini-break in the 12th point that secured his place in the quarter, setting up a clash against Rafael Nadal.
Federer seemed pleased that his opponent raised his level in the second set after a first set he described as "almost too easy".
A single break of serve was all Nadal required in the opening set and he broke twice in the second.
Federer came out firing in the opener and subsequently dismantled Mannarino in a bagel set that lasted just 16 minutes.
It's that time of the year when Tennis fans across the globe hook themselves to their TV sets and can not afford to miss even a second.
The 12th seed timed the conclusion nearly to perfection, sealing victory at 8.50 pm on his third match point after Khachanov dumped a exhausted backhand into the net to end a 20-stroke rally.
The 28-year-old Nishikori is the first Japanese man to reach the quarter-finals at Wimbledon since Shuzo Matsuoka in 1995.
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