The quick swearing in enables Kavanaugh to begin work immediately in advance of arguments at the court Tuesday in two cases involving prison sentences for repeat offenders.
Republicans said the secret document - which described interviews agents conducted with 10 witnesses - failed to find anyone who could corroborate allegations by his two chief accusers, Christine Blasey Ford and Deborah Ramirez.
"The Senate confirmation process is not a trial".
A few hundred protesters are gathering outside the Capitol before the vote.
Large groups of protesters gathered outside the Capitol building and across the street at the Supreme Court ahead of the final vote on Saturday. They chanted, "Vote them out!" If they won't listen to our voices, then they'll listen to our vote'.
Her comments on the Senate floor Friday started with interruptions with protesters yelling, "Vote no!" Trump said in a tweet.
Six University of Kentucky educators were among more than 1,200 law professors to sign a letter urging the U.S. Senate not to confirm Brett Kavanaugh's Supreme Court nomination. Later today, I will sign his Commission of Appointment, and he will be officially sworn in. Republicans have 51 seats in the Senate, which is enough to get Kavanaugh through, but not if more than one Senator vote against him.
Melania Trump is offering some supportive words for Supreme Court nominee Brett Kavanaugh.
"It certainly had a good impact for us".
Senate Democratic Leader Chuck Schumer on Friday said Kavanaugh represents "a hard-right, conservative jurisprudence, far, far away from what average Americans believe".
It was not clear that Kavanaugh would have the votes for confirmation until Collins said in a Senate floor speech that she would support his nomination.
Kavanaugh was accused of sexual misconduct by a woman who said he assaulted her at a home in suburban Washington when they were teenagers in the 1980s.
Accusations against Kavanaugh energized the #MeToo social media movement that emerged after high-profile accusations of sexual assault and harassment by men in politics, the media and the entertainment industry.
"If you appear before congress and lie, you're out, and I really wish the senators felt that way", she said.
In a chamber where Republicans hold the narrowest of majorities, all senators voted in accordance with party lines, with the exception of Democrat Joe Manchin of West Virginia, who endorsed Kavanaugh, and Alaska Republican Lisa Murkowski, who voted against.
As the debate entered its final hours, the divisions between Republicans and Democrats festered.
Without weighing in on the sexual assault allegations that Ford leveled against Kavanaugh, Mrs. Trump says victims of "any kind of abuse or violence" must be helped.
He said this type of rhetoric has been coming from the left throughout the confirmation process, so it's no surprise that the Kavanaugh debate became so heated. We can not guarantee that it is suitable for the visually or hearing impaired.
Murkowski sat solemnly during the roll call and whispered "No" when it was her turn to vote.
Murkowski voted "present", offsetting the absence of Kavanaugh supporter Steve Daines of Montana, who was attending his daughter's wedding.
The Senate is expected take an initial vote on Friday morning.
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